Category: Fibromyalgia

Andie Willis has been battling with the UK’s healthcare system since the age of 16. Andrea Willis, also known as Andie, has been battling with the UK’s healthcare system since the age of 16. Now in her 40’s she has found a treatment that works for controlling her pain and gives her a better quality of life. Andie Willis, 49, lives with constant pain due to the debilitating condition fibromyalgia, resulting in symptoms including muscle spasms, a dry mouth and constant fatigue. But fibromyalgia isn’t the only health condition Andie has…

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Fibromyalgia (FM) is a chronic pain condition that predominantly affects women. Evidence implies that FM is associated with dysfunction of the central nervous system (CNS). In this study, we investigated the structural differences between FM patients and healthy control (HC) subjects using a multivariate approach. Source-based morphometry (SBM) was applied to structural magnetic resonance imaging (sMRI) data consisting of 20 FM patients (46.4 ± 12.5), and age and gender-matched 20 HC subjects (42.1 ± 12.5). SBM revealed greater grey matter volume (GMV) in the bilateral thalamus in FM patients. Conversely, lower GMV was found…

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Fibromyalgia, Pain, and Substance Use Disorders Key points Fibromyalgia affects between 4 and 10 million and 60 million people suffer from > 3months of pain Opioid, Cannabis, and Alcohol Use Is Particularly Risky Self-Medication in Pain This Is Especially True in FM’s nociplastic pain- brain pathways involved in FM are also involved in addiction. Fibromyalgia and chronic pain create a “fertile breeding ground” for self-medication and iatrogenic addiction. . Fibromyalgia involves abnormal pain processing; the brain struggles to turn off pain signals. Many brain pathways involved in fibromyalgia are also involved in addiction.…

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In a milestone moment for chronic pain management, Tonix Pharmaceuticals announced on August 15, 2025, that its novel sublingual therapy Tonmya has received approval from the U.S. Food and Drug Administration (FDA) – marking the first new drug for Fibromyalgia in more than 15 years. The medication is now commercially available by prescription in U.S. pharmacies, offering new hope to the roughly 10 million American adults affected by this debilitating condition. A first-in-class, non-opioid approach Tonmya represents a new therapeutic class: a non-opioid, once-daily sublingual tablet designed for bedtime use.…

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With no existing cure for fibromyalgia, a chronic pain syndrome, current treatments focus on managing the symptoms like pain, fatigue and poor sleep, with exercise being a key part of the recommendations. Otherwise, the only solutions available are cognitive therapies and antidepressants, due the variability of symptoms from patient to patient. The only FDA-approved drugs to treat fibromyalgia are antidepressants duloxetine (Cymbalta) and milnacipran (Savella), and antiepileptic pregabalin (Lyrica), and drug discovery efforts have had limited success in recent years.  The 2024 FDA fast-track ruling on Tonmya (cyclobenzaprine HCl sublingual tablets) has…

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Background: Fibromyalgia (FM) is a chronic condition characterized by widespread pain, fatigue, and mood disturbances. Management often involves pharmacological and non-pharmacological interventions, but optimal treatment strategies remain unclear. Objective: To compare the effectiveness of dry needling combined with selective serotonin reuptake inhibitors (SSRIs) versus trigger point injections for pain management in fibromyalgia patients. Methods: A randomized controlled trial was conducted with 42 fibromyalgia patients. Participants were randomly assigned to Group A (dry needling with SSRIs) or Group B (trigger point injections). Pain, depression, and fibromyalgia impact were assessed using the Visual Analog Scale…

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Once dismissed by many clinicians, it is now estimated that as much as six percent of the world’s population has fibromyalgia, a complex disease in which the body is affected by pain in the joints and soft tissue. The pain may be mild to severe, though it does not damage bones or joints. Patients may also have sleep trouble, headaches, restless legs, or depression and anxiety. These symptoms can be seen in many other common disorders that affect the joints like arthritis and lupus. Diagnosing fibromyalgia can therefore be challenging, and…

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Many people living with Fibromyalgia report that something as simple as taking a shower can feel like a full-body workout. If you’ve ever stepped out of the shower feeling completely drained, shaky, or even in more pain than before—you are definitely not alone. Here’s a detailed look at why this happens and how common it is: 🌿 How Common Is Shower Exhaustion? While exact numbers vary, studies and patient reports suggest that a large percentage (often 60–80%) of people with fibromyalgia experience post-exertional fatigue from basic daily activities—including showering. In…

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Another major contributor to upper-body pain in Fibromyalgia is persistent muscle tension, especially in the neck, shoulders, and upper back. This tension is not just a simple physical issue—it is deeply connected to how the nervous system behaves in people living with fibromyalgia. The body tends to remain in a heightened state of alertness, almost like it is constantly bracing for stress or danger. As a result, muscles stay partially contracted for long periods, even when there is no real need. Over time, this continuous contraction reduces blood flow to…

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