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What do you do to calm your nervous system? My stress tolerance is very low and I find it so hard to wind down after not being “centered” all day. I’ve found stretching helps with that though. What do you do that helps you be calm and present again, if you’re triggered, stressed or anxious?   16 Simple Ways to Relieve Stress Engaging in activities that support self-care may help reduce stress and anxiety. These can include getting more exercise, mindfulness practices, and eating a well-balanced diet. Minimizing the chronic stress of…

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An obese 30-year-old African-American woman presents at a rheumatology clinic with muscle pain and tenderness to touch throughout her body. The patient, a mechanical engineer, has been referred by her primary care physician for a second assessment of diffuse myalgia accompanied by elevated inflammatory markers. She has a long and complex medical history. She has a body-mass index of 41, and does not smoke or drink alcohol. She says that she has muscle pain all over her body, but that her joints are not painful. She also reports extreme fatigue.…

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First-in-human trial tests safer T-cell therapy for pediatric brain cancers Researchers report encouraging early results from a first-in-human clinical trial led by Children’s National using a new T-cell immunotherapy for children and young adults with some of the deadliest brain tumors, including diffuse intrinsic pontine glioma (DIPG) and relapsed central nervous system (CNS) tumors. These findings, published in Nature Medicine, are particularly significant given the challenges faced in treating pediatric brain tumors, which remain the leading cause of cancer-related deaths in children. Immunotherapies have been shown to work in blood cancers…

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Key Takeaways Alkermes initiated three pivotal 12-week, randomized, double-blind trials comparing alixorexton with placebo in narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia. Mechanistically, selective OX2R agonism is intended to activate wake-promoting pathways and may mitigate excessive daytime sleepiness irrespective of whether orexin deficiency is etiologic. SHOW MORE Alkermes has initiated a phase 3 clinical program evaluating alixorexton for narcolepsy type 1 and type 2, with additional development underway for idiopathic hypersomnia. Alkermes has begun its safety and efficacy trials of alixorexton for the treatment of narcolepsy type 1…

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Fibromyalgia is a common chronic disorder that is characterized by widespread pain, among other symptoms. It can cause significant pain and fatigue, interfering with a person’s ability to carry out their daily activities. While the causes of fibromyalgia are unknown, it’s estimated that it affects 5 million Americans ages 18 or older. Research has shown that fibromyalgia patients typically see several different doctors before receiving their diagnosis. The symptoms of fibromyalgia often mimicked other health issues, which can make it hard to diagnose. Understanding the symptoms can help a patient identify their…

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